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Peptide backbone
Peptide backbone




DALI and the persistence of protein shape. An NMR approach to structural proteomics. Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues. Reagent for the detection of protein thiocarboxylates in the bacterial proteome: lissamine rhodamine B sulfonyl azide. Mechanistic basis for ribosomal peptide backbone modifications. Comparative genomics highlights the unique biology of Methanomassiliicoccales, a Thermoplasmatales-related seventh order of methanogenic archaea that encodes pyrrolysine. The EFI web resource for genomic enzymology tools: leveraging protein, genome, and metagenome databases to discover novel enzymes and metabolic pathways. Biosynthesis of thiocarboxylic acid-containing natural products. Protein thiocarboxylate-dependent methionine biosynthesis in Wolinella succinogenes. The cluster of sulfurtransferase TtuA desulfurizes TtuB during tRNA modification in Thermus thermophilus.

peptide backbone

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. Crystal structure of molybdopterin synthase and its evolutionary relationship to ubiquitin activation. The biosynthesis of the thiazole phosphate moiety of thiamin: the sulfur transfer mediated by the sulfur carrier protein this. Structure of the Escherichia coli ThiS–ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis. Ubiquitin-like proteins and their roles in archaea. nov., isolated from freshwater sediment, a methylotrophic methanogen able to grow on dimethyl sulfide and methanethiol. Isolation and characterization of Methanomethylovorans hollandica gen. Cysteine is not the sulfur source for iron-sulfur cluster and methionine biosynthesis in the methanogenic archaeon Methanococcus maripaludis. Liu, Y., Sieprawska-Lupa, M., Whitman, W. Post-translational modifications in the active site region of methyl-coenzyme M reductase from methanogenic and methanotrophic archaea. Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans. The key nickel enzyme of methanogenesis catalyses the anaerobic oxidation of methane. Scheller, S., Goenrich, M., Boecher, R., Thauer, R. Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation. A newly discovered gene, tfuA, involved in the production of the ribosomally synthesized peptide antibiotic trifolitoxin. Uncovering the unexplored diversity of thioamidated ribosomal peptides in Actinobacteria using the RiPPER genome mining tool.

peptide backbone

Thioholgamides: thioamide-containing cytotoxic RiPP natural products. A genomics-based approach identifies a thioviridamide-like compound with selective anticancer activity. Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis. Biosynthesis and chemical applications of thioamides. Structure of the bacterial ribosome at 2 Å resolution. Enzymatic reconstitution of ribosomal peptide backbone thioamidation. Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea.

peptide backbone

Bioinformatic expansion and discovery of thiopeptide antibiotics. New developments in RiPP discovery, enzymology and engineering. Structural analysis of leader peptide binding enables leader-free cyanobactin processing. A prevalent peptide-binding domain guides ribosomal natural product biosynthesis. Identification of an auxiliary leader peptide-binding protein required for azoline formation in ribosomal natural products. Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis. YcaO-dependent posttranslational amide activation: biosynthesis, structure, and function. YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations. UniProt: the universal protein knowledgebase. The Pfam protein families database in 2019.






Peptide backbone